Christopher E. Lawson

Automated anaerobic cultivation and phenotyping of diverse chain-elongating bacteria

This study develops an automated system for anaerobic cultivation and phenotyping of chain-elongating bacteria, revealing metabolic diversity and chain-length specificity principles.

Engineering anaerobic fungal-bacterial consortia for direct conversion of lignocellulosic biomass into medium-chain fatty acids

This study engineers an anaerobic fungal-bacterial consortium to convert lignocellulosic biomass into medium-chain fatty acids without pretreatment, achieving a 21.0% conversion yield.

Coupling Stickland fermentation with reverse β-oxidation represents a new mode of medium-chain carboxylate production

This study identifies a novel metabolic pathway in chain elongating bacteria that couples Stickland fermentation with reverse β-oxidation to produce medium-chain carboxylic acids.

Peptonella octanoica gen. nov., sp. nov., a new medium-chain carboxylate-producing bacterium, and the reclassification of Eubacterium pyruvativorans as Peptonella pyruvativorans comb. nov.

The paper describes a new bacterial species, Peptonella octanoica, and reclassifies Eubacterium pyruvativorans into this genus based on phylogenetic and phenotypic analysis.

Long-term Production and Recovery of Medium-Chain Carboxylates from Source-Separated Organics

This study demonstrates long-term production and recovery of medium-chain carboxylic acids from source-separated organics using microbial chain elongation and in-line extraction.

Distinct Acetate Utilization Strategies Differentiate Butyrate and Medium-Chain Carboxylic Acid Producing Chain-Elongating Bacteria

The paper identifies distinct acetate utilization strategies in chain-elongating bacteria that explain differences in butyrate versus medium-chain carboxylic acid production.

Enabling Plasmid-based Expression in Clostridium kluyveri using a Biparental Methylation-Conjugation System

This paper develops a methylation-conjugation system for Clostridium kluyveri to enable plasmid-based genetic modification and demonstrates its use for expressing a fluorescent reporter.

CAZyme domain architectures suggest fine-scale functional differentiation among anaerobic fungi and bacteria during lignocellulose conversion to volatile fatty acids

Evaluating the feasibility of medium chain oleochemical synthesis using microbial chain elongation

This study evaluates the feasibility of expanding the product range of chain elongating bacteria to produce C9-C12 fatty acids and other derivatives using metabolic engineering and constraint-based modelling.

A general approach to explore prokaryotic protein glycosylation reveals the unique surface layer modulation of an anammox bacterium.

This paper introduces a mass binning glycoproteomics approach to explore prokaryotic protein glycosylation, revealing unique surface layer modulation in an anammox bacterium.

Metatranscriptomic and thermodynamic insights into medium-chain fatty acid production using an anaerobic microbiome

The paper integrates metagenomic, metatranscriptomic, and thermodynamic analyses to predict and characterize the metabolic network of an anaerobic microbiome producing medium-chain fatty acids from renewable feedstock.