Samuel Ghatan

Identification of target genes and regulatory networks for bone mineral density GWAS loci through systematic targeting and inhibition

The paper identifies target genes and regulatory networks for bone mineral density GWAS loci using STING-seq, linking noncoding variants to gene function in osteoblasts.

Integrating multi-omic QTLs and predictive models reveals regulatory architectures at immune-related GWAS loci in CD4+ T cells

The paper integrates multi-omic QTLs and predictive models to identify regulatory variants in CD4+ T cells and their role in immune-related GWAS loci.

Non-linear transcriptional responses to gradual modulation of transcription factor dosage

This study modulates gene dosage using CRISPR and examines nonlinear transcriptional responses to dosage changes in three master transcription factors, revealing non-monotonic effects and links to disease genes.

Genetic Nurture: Estimating the direct genetic effects of pediatric anthropometric traits

This study estimates direct and indirect genetic effects on pediatric anthropometric traits in a Dutch cohort, finding significant direct effects but limited indirect genetic nurture influence.

CRISPRi perturbation screens and eQTLs provide complementary and distinct insights into GWAS target genes

The paper compares CRISPRi perturbation screens and eQTLs in identifying target genes for GWAS-associated loci, finding they often identify distinct genes and complement each other.