Laure Yatime

Teleost-specific ictacalcins exhibit similar structural organization, cation-dependent activation and transcriptional regulation as human S100 proteins

The paper characterizes two teleost-specific S100 proteins, S100i1 and S100i2, showing they share structural, functional, and expression features with mammalian S100 proteins.

Verapamil limits inflammation by restoring VGCC-driven epithelial Ca2+ in models of cystic fibrosis

This study shows verapamil reduces inflammation in cystic fibrosis by normalizing epithelial calcium signaling and oxidative stress in zebrafish and human cells.

Importance of cysteines for the binding of S100A6 to the RAGE receptor - Towards a first molecular model for S100 covalent dimerization

This study shows that cysteine residues are critical for S100A6 binding to RAGE and reveals a covalent dimerization mechanism in S100 proteins.

Curcumin-mediated NRF2 induction limits inflammatory damage in preclinical models of cystic fibrosis

This study shows curcumin improves inflammation and tissue damage in cystic fibrosis by restoring NRF2 activity in zebrafish and patient-derived airway organoids.