Author

Georges Lutfalla

Centre National de la Recherche ScientifiqueORCID 0000-0002-6591-7894Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:zebrafish· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Assay:imaging· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Jean‐Pierre LevraudiD· 2 shared Akshai Janardhana KurupiD· 1 shared Annamaria PedotoiD· 1 shared Audrey BernutiD· 1 shared Aya MikdacheiD· 1 shared Bastien SuireiD· 1 shared Camila Garcia-BaudinoiD· 1 shared Carmen Gloria FeijóoiD· 1 shared

Activity by Year

2025-2025 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersImmunology

Jean‐Pierre LevraudORCID

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Author profile →

4 papers

Recent·Most cited

The two groups of zebrafish type I interferons target different tissues, paralleling the mammalian type I: type III IFN functional division

Hannah Wiggett, Dean Porter, Valérie Briolat, Teodosia Balaboi, Maroun Abi Younes, Ingrid Colin, Georges Lutfalla, Jean‐Pierre Levraud

This study shows zebrafish type I interferons target different tissues, mirroring the mammalian division between type I and type III IFNs.

bioRxiv · Nov 3, 2025 · PreprintImmunology

Verapamil limits inflammation by restoring VGCC-driven epithelial Ca2+ in models of cystic fibrosis

Sarahdja Cornélie, Bastien Suire, Sylvaine Huc-Brandt, Laure Yatime, Christian Dupont, Stephen A. Renshaw, Georges Lutfalla, R. Andrés Floto, Céline Cougoule, Audrey Bernut

This study shows verapamil reduces inflammation in cystic fibrosis by normalizing epithelial calcium signaling and oxidative stress in zebrafish and human cells.

bioRxiv · Oct 12, 2025 · PreprintImmunology

Interleukin-22 in enteroendocrine cells controls early-life gut motility through interactions with the microbiota

Soraya Rabahi, Emiliano Marachlian, Fabian Guendel, Aya Mikdache, Keinis Quintero-Castillo, Lucie Maurin, Vincenzo Di Donato, Akshai Janardhana Kurup, Yazan Salloum, Gwendoline Gros, Patricia Diabangouaya, Camila Garcia-Baudino, Ignacio Medina-Yáñez, Jean‐Pierre Levraud, Georges Lutfalla, , Pedro P. Hernández

This study shows that IL-22 from enteroendocrine cells in zebrafish larvae controls gut microbiota and motility, with similar effects observed in mice.

bioRxiv · Apr 25, 2025 · PreprintImmunology

Macrophage Inflammasome Activation Drives Anti-inflammatory Responses via Neutrophil-Derived ASC Speck Transfer and Gasdermin-Dependent Caspase-1 Inhibition

Annamaria Pedoto, Juan M. Lozano Gil, Mai Nguyen Chi, Georges Lutfalla, Diana García‐Moreno, María Luisa Cayuela, Sylwia D. Tyrkalska, Víctoriano Mulero

This study shows macrophage inflammasomes drive anti-inflammatory responses by transferring neutrophil-derived ASC specks and inhibiting caspase-1 via Gasdermin E.

bioRxiv · Jan 22, 2025 · PreprintImmunology