Yaomin Xu

The Cardiovascular Benefit of Menopause Hormone Treatment is Age-Dependent in Ldlr-/- Mice

This study shows that menopause hormone treatment (E2) reduces atherosclerosis in young mice but not older mice, due to age-related changes in inflammation and estrogen receptor signaling.

Genetic drivers and clinical consequences of mosaic chromosomal alterations in 1 million individuals

The paper identifies genetic drivers and clinical consequences of mosaic chromosomal alterations in 1 million individuals, linking specific aut-mCAs to disease risk and therapeutic targets.

Risk of Incident Cytopenia in Clonal Hematopoiesis

The paper analyzes sequencing data from three cohorts to quantify cytopenia incidence and identify risk factors in clonal hematopoiesis, finding higher cytopenia rates and progression to myeloid neoplasms.

Cost-effective and scalable clonal hematopoiesis assay provides insight into clonal dynamics

The paper introduces a cost-effective CHIP assay, identifies 101 CHIP cases in a cohort, and finds heterogeneity in clonal expansion rates by driver gene and individual.

Identifying modifiable comorbidities of schizophrenia by integrating electronic health records and polygenic risk

This study identifies modifiable comorbidities of schizophrenia by analyzing EHR data and polygenic risk scores, finding conditions with no shared genetic risk that may be influenced by treatment or environment.

Single-nuclear RNA sequencing of endomyocardial biopsies identifies persistence of donor-recipient chimerism with distinct signatures in severe cardiac allograft vasculopathy

Genomic and phenomic landscape of clonal hematopoiesis in over a million ancestrally diverse participants

This study analyzes clonal hematopoiesis in over a million diverse individuals, identifying 72 genome-wide significant loci and linking CHIP to various phenotypes.

Temporal changes in genetic admixture are linked to heterozygosity and health diagnoses in humans

The paper examines how changes in genetic admixture over time affect heterozygosity and health outcomes in a southeastern U.S. population.

Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data

quanTIseq estimates absolute fractions of ten immune cell types from bulk RNA-seq; across TCGA, CXCL9/CXCR3 expression, not mutational load, tracks CD8+ T cell infiltration.