Anne E. Clatworthy

Kainate receptors coordinate primitive hematopoiesis and hemogenic niche organization to promote hematopoietic stem cell development

This study identifies kainate receptors' role in coordinating primitive hematopoiesis and hemogenic niche organization in zebrafish, showing their impact on hematopoietic stem cell development through endothelial Notch signaling.

Kmo restricts Salmonella in a whole organism infection model by promoting macrophage lysosomal acidification through kainate receptor antagonism.

The paper shows that Kmo produces 3-HK, which promotes macrophage lysosomal acidification via kainate receptor antagonism, enhancing resistance to Salmonella infection.

Mapping genetic and phenotypic diversity of Pseudomonas aeruginosa across clinical and environmental isolation sites

The paper analyzes 125 Pseudomonas aeruginosa isolates from clinical and environmental sources to assess genotype-phenotype correlations and niche specialization, finding that genomic diversity does not correlate with isolation source or most virulence traits, but Group B strains show higher cytotoxicity.

Generation of Mouse-Zebrafish Hematopoietic Tissue Chimeric Embryos for Hematopoiesis and Host-Pathogen Interaction Studies

This study xenografts murine bone marrow cells into zebrafish embryos to study hematopoiesis and host-pathogen interactions, showing successful integration and immune response.