Author

George F. Murphy

Brigham and Women's HospitalORCID 0000-0002-3909-1160Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:scRNA-seq· 2 Assay:ATAC-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Alexandru M. PleşaiD· 1 shared Alicia M. McConnelliD· 1 shared Anaïs EberhardtiD· 1 shared Andrew L. JiiD· 1 shared Anna MandinovaiD· 1 shared Asaf Ashkenazy-Titelman· 1 shared Chloé S. BaroniD· 1 shared Christine Guo LianiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperSynthetic Biology

Alexandru M. PleşaORCID

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2 papers

Recent·Most cited

Human skin rejuvenation via mRNA

Li Li, Zhengkuan Tang, Xavier Portillo, Rohit Arora, Madeleine Yang, Esther Mintzer, Zhenrui Zhang, Stefano Sol, Fabiana Boncimino, Patrick Han, Michelle Z. Dion, Emery Di Cicco, D.D. Majewski, Asaf Ashkenazy-Titelman, Alexandru M. Pleşa, , George McDonald Church

This paper presents a single-cell atlas of skin aging and identifies ATF3 as a regulator of aging, leading to an mRNA-based treatment that reduces cell senescence and enhances skin rejuvenation.

Journal of Investigative Dermatology · Jul 21, 2026Peer-reviewedSynthetic Biology

BMP-dependent oligoclonal cancer attractor state precedes neural crest fate in melanoma initiation

Alicia M. McConnell, Maggie H. Chassé, Haley R. Noonan, Jeffrey K. Mito, Julia Barbano, Erika Weiskopf, Irene F. Gosselink, Song P. Yang, Kyle D. Drake, Chloé S. Baron, Elise Layne, Meera Prasad, Phammela Abarzua, Maxime Grimont, Yung-Ching Kao, , Leonard Ira Zon

The paper identifies a BMP-dependent attractor state in melanoma precursor cells that precedes neural crest fate and is associated with ID1 expression in human melanoma.

bioRxiv · Oct 22, 2024 · PreprintCancer Biology