Author

Ilgar Z. Mamedov

Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and ImmunologyORCID 0000-0002-3992-9285Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Research Focus:perturbation response prediction· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Alexander G. GabiboviD· 1 shared Alexander Yu. KomkoviD· 1 shared Alexey V. StepanoviD· 1 shared Anastasia A. MinervinaiD· 1 shared Daria S. OsipovaiD· 1 shared Ding ZhangiD· 1 shared Dmitry PershiniD· 1 shared Dmitry V. VolkoviD· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperMolecular Biology

Alexander G. GabibovORCID

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2 papers

Recent·Most cited

Targeting CD45 by gene-edited CAR-T cells for leukemia eradication and hematopoietic stem cell transplantation preconditioning

Valeria M. Stepanova, Dmitry V. Volkov, Daria S. Osipova, Wenjian Wang, Yingqin Hou, Dmitry Pershin, Maria Fadeeva, Ekaterina A. Malakhova, Elena A. Kulakovskaya, LYU Cuicui, Zhao Mingfeng, Hongkai Zhang, Jia Xie, Ding Zhang, Ilgar Z. Mamedov, , Alexey V. Stepanov

This paper demonstrates the preclinical efficacy of CD45-targeting CAR T and NK cells for leukemia treatment and HSCT preconditioning, showing reduced fratricide through gene editing.

Molecular Therapy Oncology · Jun 27, 2024Peer-reviewedMolecular Biology

Genomic normalization for sequencing libraries enrichment for rare somatic retroelement insertions

Alexander Yu. Komkov, Gaiaz A. Nugmanov, Maria Salutina, Anastasia A. Minervina, Konstantin V. Khodosevich, Yuri B. Lebedev, Ilgar Z. Mamedov

This study develops a normalization procedure to enhance detection of rare somatic retroelement insertions in sequencing libraries, increasing identified insertions by 7.9-fold.

bioRxiv · Mar 29, 2018 · PreprintGenomics