Author

Wenjian Wang

Scripps Research InstituteORCID 0000-0002-1880-3050Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:flow cytometry· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Yingqin HouiD· 2 shared Alexander G. GabiboviD· 1 shared Alexey V. StepanoviD· 1 shared Daria S. OsipovaiD· 1 shared Digantkumar Gopaldas ChaplaiD· 1 shared Ding ZhangiD· 1 shared Dmitry PershiniD· 1 shared Dmitry V. VolkoviD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCancer Biology

Yingqin HouORCID

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2 papers

Recent·Most cited

Enforced E-selectin ligand installation enhances homing and efficacy of adoptively transferred T cells

Yingqin Hou, Jinfeng Ye, Ke Qin, Leigh-Ann Cui, Shereen Chung, Digantkumar Gopaldas Chapla, Wenjian Wang, Yujie Shi, Mingkuan Chen, Kelley W. Moremen, Robert Sackstein, Peng Wu

This study shows that exofucosylation of T cells enhances their homing and therapeutic efficacy in treating solid tumors and metastases.

bioRxiv · Jan 12, 2025 · PreprintCancer Biology

Targeting CD45 by gene-edited CAR-T cells for leukemia eradication and hematopoietic stem cell transplantation preconditioning

Valeria M. Stepanova, Dmitry V. Volkov, Daria S. Osipova, Wenjian Wang, Yingqin Hou, Dmitry Pershin, Maria Fadeeva, Ekaterina A. Malakhova, Elena A. Kulakovskaya, LYU Cuicui, Zhao Mingfeng, Hongkai Zhang, Jia Xie, Ding Zhang, Ilgar Z. Mamedov, , Alexey V. Stepanov

This paper demonstrates the preclinical efficacy of CD45-targeting CAR T and NK cells for leukemia treatment and HSCT preconditioning, showing reduced fratricide through gene editing.

Molecular Therapy Oncology · Jun 27, 2024Peer-reviewedMolecular Biology