Howard S. Fox

This paper identifies a pathway where dopamine induces mitochondrial dysfunction in macrophages, leading to IL-6 secretion via the cGAS-STING pathway.

This study shows cocaine enhances HIV infection of microglia via sigma-1 activation, which modulates the UPR to boost viral replication and immune evasion.

This study uses single-nucleus multiome sequencing to identify HIV-associated transcriptional and epigenetic changes in brain regions of individuals with HIV, revealing altered glial cell states and pro-inflammatory signaling.

This study uses single-cell RNA sequencing to analyze microglia and macrophages in rhesus macaques during acute SIV infection, revealing changes in cell clusters and gene expression linked to inflammation and neurodegeneration.

This study shows dopamine increases IL-1β in myeloid cells via differential dopamine receptor expression, and this effect is exacerbated by HIV.

This study shows morphine suppresses immune responses and alters brain myeloid gene expression in SIV-infected macaques, promoting neuropathogenesis.

This study shows that chronic morphine administration reduces SIV reservoirs in peripheral blood and lymph nodes but increases them in CNS microglia/macrophages in SIV-infected rhesus macaques.