Keisuke Ito

A vagal sensory pathway for satiety suppression by intestinal fructose

The paper identifies a vagal sensory pathway activated by intestinal fructose that does not suppress food intake, unlike glucose, potentially contributing to overconsumption of fructose.

Aberrant oxidative metabolism selects for TET2-deficient hematopoietic stem and progenitor cells

This study shows that aberrant oxidative metabolism drives the selection of TET2-deficient hematopoietic stem and progenitor cells in clonal hematopoiesis, with the pentose phosphate pathway playing a compensatory role.

A STAT3 Degrader Demonstrates Pre-clinical Efficacy in Venetoclax resistant Acute Myeloid Leukemia

This paper shows that targeting STAT3 with a degrader can overcome Venetoclax resistance in AML by reducing MCL1 and improving mitochondrial function.

Elevated endocytic trafficking mediated by GPRASP2 maintains HSC fidelity.

The paper shows that elevated endocytic trafficking via GPRASP2 maintains HSC quiescence and prevents functional exhaustion.

Systematic functional dissection of germline noncoding risk variants impacting clonal hematopoiesis

The paper identifies non-coding variants associated with clonal hematopoiesis and demonstrates their regulatory impact on gene expression and clonal expansion.

Lactate dehydrogenase A-coupled NAD+ regeneration is critical for acute myeloid leukemia cell survival

This study shows that LDHA is essential for maintaining NAD+/NADH balance in AML cells, and its inhibition leads to cell death, suggesting it as a therapeutic target.

Deep Learning-Based Inference of Uterine Contractions from Maternal ECG

This paper develops a deep learning algorithm to infer uterine contractions from maternal ECGs, achieving a Pearson correlation coefficient of 0.53 with ground truth data.