Author
Columbia University Irving Medical CenterORCID 0000-0002-8620-827XUnclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Tianle Chen, Francesca Vallese, Eva Gil‐Iturbe…·Emad Tajkhorshid
This study uses cryo-EM and molecular dynamics to analyze conformational transitions in AE1 and shows how PIP2 lipids inhibit transport by stabilizing the outward-facing state.
Mariko Kanai, Sachel Mok, Tomas Yeo…·David A. Fidock
This study identifies DMT1 and a chromosome 12 locus, including FtsH1, as novel contributors to Plasmodium falciparum resistance to quinine, alongside the known pfcrt gene.
Alexandra C. Schwartz, Richard A. Stein, Eva Gil‐Iturbe…·Hassane S. Mchaourab
This paper uses AlphaFold2 and DEER spectroscopy to study the conformational dynamics of MhsT, revealing energy landscapes and environmental effects on transporter function.
Sachel Mok, Tomas Yeo, Davin Hong…·David A. Fidock
The paper identifies genetic determinants of multidrug resistance in Plasmodium falciparum and their impact on parasite fitness and drug susceptibility.
Silas A. Buck, Sophie A. Rubin, Tenzin Kunkhyen…·Zachary Freyberg
This study identifies VGLUT-mediated mechanisms protecting DA neurons from PD-related degeneration, revealing sex-specific effects and transcriptional regulators.