Author

Lutz Tautz

Sanford Burnham Prebys Medical Discovery InstituteORCID 0000-0002-4075-6238Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

Jiaqian WuiD· 2 shared A. ChaikuadiD· 1 shared Ali EbrahimiD· 1 shared Allison S. LimpertiD· 1 shared Anthony C. BishopiD· 1 shared Betsaida Bibo‐Verdugo· 1 shared Blake T. RileyiD· 1 shared D.A. KeedyiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

Jiaqian WuORCID

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2 papers

Recent·Most cited

Synthesis and Characterization of ULK1/2 Kinase Inhibitors that Inhibit Autophagy and Upregulate Expression of Major Histocompatibility Complex I for the Treatment of Non-Small Cell Lung Cancer

Fabiana Izidro Layng, Huiyu Ren, Nicole A. Bakas, Dhanya R. Panickar, Lester J. Lambert, Maria Celeridad, Jiaqian Wu, Laurent J. S. De Backer, Preeti Chandrachud, Allison S. Limpert, Mitchell Vamos, A. Chaikuad, Betsaida Bibo‐Verdugo, Patrick M. Hagan, Sonja N. Brun, , Nicholas D. P. Cosford

The paper reports the design, synthesis, and characterization of new ULK1/2 inhibitors that inhibit autophagy and upregulate MHC I in NSCLC cells, supporting their potential as cancer therapeutics.

ACS Chemical Biology · Feb 12, 2026Peer-reviewedCancer Biology

Three STEPs forward: A trio of unexpected structures of PTPN5

Liliana Guerrero, Ali Ebrahim, Blake T. Riley, Sean Kim, Anthony C. Bishop, Jiaqian Wu, Ye Na Han, Lutz Tautz, D.A. Keedy

This study presents three new crystal structures of STEP (PTPN5) revealing unexpected conformational features and ligand binding events that provide insights for structure-based drug design.

Proteins Structure Function and Bioinformatics · Jul 5, 2025Peer-reviewedBiophysics