Emma L. Fritsch

Evaluating the effects of aging on biodistribution and gene silencing activity of lipid-siRNA conjugates delivered into cerebrospinal fluid

This study evaluates how aging affects the distribution and gene silencing activity of lipid-siRNA conjugates in the cerebrospinal fluid of mice.

Correspondence between sleep patterns and anhedonia in adult male mice exposed to early-life stress

This study examines the relationship between sleep patterns and anhedonia in male mice exposed to early-life stress, finding significant correlations between sleep architecture and anhedonic phenotypes.

Lipid-siRNA conjugate accesses a perivascular transport mechanism and achieves widespread and durable knockdown in the central nervous system

This study develops a lipid-siRNA conjugate that uses perivascular transport to achieve long-lasting gene knockdown in the CNS without toxicity.

Differential effects of the stress peptides PACAP and CRF on sleep architecture in mice

This study investigates how PACAP and CRF, two stress peptides, affect sleep architecture in mice, finding distinct impacts on sleep stages and behavior.

Early life stress in male mice blunts responsiveness in a translationally-relevant reward task

This study shows that early-life stress in male mice reduces response bias for highly rewarded stimuli in a translational reward task, suggesting potential parallels with human depression.