Author

Massimo Cristofanilli

Weill Cornell MedicineORCID 0000-0002-4194-7175Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Carolina ReduzziiD· 2 shared David ScholteniD· 2 shared Deyu FangiD· 2 shared Fangjia Tong· 2 shared Hannah Faisal AlmubarakiD· 2 shared Huiping LiuiD· 2 shared Leonidas C. PlataniasiD· 2 shared William John GradishariD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersBiochemistry

Carolina ReduzziORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Improved surfactant-assisted one-pot sample preparation for robust convenient single cell proteomics

Reta Birhanu Kitata, Zhangyang Xu, Nadia Bayou, Rui Zhao, William B. Chrisler, Matthew J. Gaffrey, Karl Weitz, Mara Serena Serafini, Elisabetta Molteni, Vladislav Petyuk, Massimo Cristofanilli, Tao Liu, Carolina Reduzzi, Tujin Shi

This paper introduces an improved single-cell proteomics method, iSOP-MS, which enhances robustness and convenience for quantitative analysis by using a low-volume 384-well plate and optimized enzyme mixtures.

Journal of Proteome Research · Jul 10, 2026Peer-reviewedBiochemistry

AI-enabled Spatial Profiling of Circulating Tumor-Immune Ecosystems Predicts Patient Outcomes Across Cancers

Joshua R Squires, Yuanfei Sun, Andrew Hoffmann, Youbin Zhang, Hao Pan, Fangjia Tong, Yiwen He, David Scholten, Hannah Faisal Almubarak, Michael J. Gurley, Allegra C. Minor, Anmol Singh, James Zhang, Hannah Ding, Chengsheng Mao, , Huiping Liu

The paper develops an AI framework to analyze blood scans and predict patient outcomes by characterizing tumor-immune ecosystems in circulation.

bioRxiv · Jul 3, 2026 · PreprintCancer Biology

Rare Subset of T Cells Form Heterotypic Clusters with Circulating Tumor Cells to Foster Cancer Metastasis

David Scholten, Lamiaa El-Shennawy, Yuzhi Jia, Youbin Zhang, Elizabeth Hyun, Carolina Reduzzi, Andrew Daniel Hoffmann, Hannah Faisal Almubarak, Fangjia Tong, Nurmaa Khund Dashzeveg, Yuanfei Sun, Joshua R. Squires, Janice Lu, Leonidas C. Platanias, Clive Henry Wasserfall, , Huiping Liu

The paper identifies a rare subset of CD4 and CD8 double positive T cells that form clusters with circulating tumor cells, promoting cancer metastasis through immune suppression and integrin-mediated interactions.

bioRxiv · Apr 1, 2025 · PreprintCancer Biology