The paper uses artificial neural networks to classify neurotransmitters from electron microscopy images of Drosophila melanogaster synapses, achieving high accuracy and revealing ultrastructural differences.

Cell · May 1, 2024Peer-reviewedNeuroscience

A Connectome of the Male Drosophila Ventral Nerve Cord

Shin-ya Takemura, Kenneth J. Hayworth, Gary B. Huang, Michał Januszewski, Zhiyuan Lu, Elizabeth C. Marin, Stephan Preibisch, C. Shan Xu, John Bogovic, Andrew S Champion, Han SJ Cheong, Marta Costa, Katharina Eichler, William T. Katz, Christopher J. Knecht, , Stuart Berg

Roughly 23 thousand traced neurons and 10 million TBars of the male Drosophila nerve cord, reconstructed from electron microscopy, typed, and queryable in neuPrint down to motor neurons.

bioRxiv · Jun 5, 2023 · PreprintNeuroscience✦ In-depth digest

A Connectome and Analysis of the Adult Drosophila Central Brain

Louis K. Scheffer, C. Shan Xu, Michał Januszewski, Zhiyuan Lu, Shin-ya Takemura, Kenneth J. Hayworth, Gary B. Huang, Kazunori Shinomiya, Jeremy Maitin-Shepard, Stuart Berg, Jody Clements, Philip M. Hubbard, William T. Katz, Lowell A. Umayam, Ting Zhao, , Gregory S.X.E. Jefferis

The paper presents a detailed connectome of the adult Drosophila central brain, including new methods for data analysis and biological insights into neural circuit organization.

eLife · Sep 3, 2020Peer-reviewedBioinformatics

A Connectome of the Adult Drosophila Central Brain

C. Shan Xu, Michał Januszewski, Zhiyuan Lu, Shin-ya Takemura, Kenneth J. Hayworth, Gary B. Huang, Kazunori Shinomiya, Jeremy Maitin-Shepard, David Ackerman, Stuart Berg, Tim M. Blakely, John Bogovic, Jody Clements, Tom Dolafi, Philip M. Hubbard, , Ian A. Meinertzhagen

A dense electron-microscopy reconstruction of half the fly central brain, with nearly every cell typed and queryable online, turns months of tracing partners into a database lookup.

bioRxiv · Jan 21, 2020 · PreprintNeuroscience✦ In-depth digest