Structural Basis for the Inhibition of the RNA-Dependent RNA Polymerase from SARS-CoV-2 by Remdesivir
Wanchao Yin, Chunyou Mao, Xiaodong Luan, Dandan Shen, Qingya Shen, Haixia Su, Xiaoxi Wang, Fulai Zhou, Wenfeng Zhao, Minqi Gao, Shenghai Chang, Yuanchao Xie, Guanghui Tian, He‐wei Jiang, Sheng‐ce Tao, , H. Eric Xu
This study reports the structure of SARS-CoV-2 RdRp with and without Remdesivir, showing how the drug inhibits viral RNA replication by terminating chain elongation.
Science · May 1, 2020Peer-reviewedMolecular Biology