Jane-Jane Chen

Oxidative Stress and Interferon Signaling Drive Differential Pathogenesis of Ancestral and Contemporary Zika Viruses in Human Cerebral Organoids

This study compares pathogenesis of ancestral and contemporary Zika viruses in human cerebral organoids, finding differential signaling responses and identifying ROS imbalance as a key driver, which is mitigated by Trolox.

The Erythropoietin Receptor Stimulates Rapid Cycling and Formation of Larger Red Cells During Mouse and Human Erythropoiesis

This study shows that EpoR signaling accelerates cell cycling and increases red cell size in mouse and human erythropoiesis, independent of HRI and not due to reticulocyte increase.

Iron and Heme Coordinate Erythropoiesis through HRI-Mediated Regulation of Protein Translation and Gene Expression

The paper investigates how iron, heme, and HRI regulate protein translation and gene expression in erythroblasts during iron deficiency, identifying novel pathways and regulators of erythropoiesis.