Marina R. Picciotto

This study identifies a dysfunctional nucleus accumbens ensemble in Shank3-/- mice that drives social avoidance by hyperresponding to social novelty.

The paper identifies proteomic changes in mPFC synaptosomes of mice exposed to inescapable stress, highlighting muscarinic receptor alterations and signaling pathway disruptions linked to depression.

The paper identifies a GABAergic pathway from the VTA to the VP that encodes unconditioned reward value and influences value-based decision-making in mice.

This study investigates the effects of noradrenergic signaling in the basolateral amygdala on coping behavior and neuronal activity in mice, finding bidirectional effects based on stimulation frequency.

This study identifies an anterior cingulate cortex neuronal ensemble that mediates context-based opioid analgesic tolerance without affecting basal nociception.

This study identifies SOX4, SOX11, and TFAP2D as critical regulators of ventropallial excitatory neuron development and PFC connectivity in mice, with conserved roles in humans.

This study investigates how ketamine affects GABAergic and glutamatergic activity in the mPFC, showing a biphasic effect on GABA neurons and their role in sustained antidepressant responses.

This study investigates the role of acetylcholine signaling in the medial prefrontal cortex during learned helplessness training and active avoidance tasks, finding sex-specific effects on escape performance and potential contributions to depressive symptoms.

The paper shows that alternative translation initiation sites produce proteoforms with distinct localization and functions, specifically in synaptic organizers like NPR and C1q-like proteins.

This study shows that stress increases alcohol consumption in female mice but not males, and microglial depletion reduces stress-induced drinking in females.

The paper identifies basal forebrain cholinergic neurons as essential partners in threat memory engrams, showing distinct activation patterns for learned and innate threats.

This study shows that acetylcholine modulates GABAergic signaling in the basolateral amygdala, altering the balance of inhibitory neuron subtypes and affecting stress-related behaviors.

This paper describes a novel mouse model of focal limbic seizures that correlates behavioral impairment with cortical slow wave activity, similar to human temporal lobe seizures.

This study examines how repeated social stress affects reward behavior and prefrontal cortical activity in mice, showing that neural responses diverge over time between resilient and susceptible animals.

The paper shows that acetylcholine in the basolateral amygdala increases during reward-related events and enhances learning of cue-reward associations in mice.