Author

Neil G. Ruthen

Memorial Sloan Kettering Cancer CenterORCID 0000-0002-4409-9503Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:phylogenetics / evolution· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

A. M. SalehiD· 1 shared Akira YokoyamaiD· 1 shared Alejandro GarcésiD· 1 shared Alexandre Pellan ChengiD· 1 shared Andrew R. D’Avino· 1 shared Barun PradhaniD· 1 shared Carolina E. EcheverríaiD· 1 shared Catherine J. PotenskiiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperCancer Biology

A. M. SalehORCID

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2 papers

Recent·Most cited

BRCA2 loss drives a PKM1-dominant glycolytic state that is selectively lethal to pyruvate kinase activation

Maira Di Tano, Mujmmail Ahmed, Shiri Li, Michael Lyashenko, Neil G. Ruthen, Ethan Tse, Isaac Nathoo, Carolina E. Echeverría, Jack Sanford, A. M. Saleh, Jeshua Kim, Ezequiel Carlos Dantas, Davide Pradella, Rhee Kyu, Ed Reznik, , Marcus DaSilva Goncalves

The paper shows BRCA2 loss leads to a PKM1-dominant glycolytic state that can be targeted with PKM activators to kill HRD tumors.

bioRxiv · Sep 29, 2026 · PreprintCancer Biology

Large-scale single-cell phylogenetic mapping of clonal evolution in the human aging esophagus

Tamara Prieto, Dennis J. Yuan, John Zinno, Clayton Hughes, Nicholas Midler, Sheng Kao, Jani Huuhtanen, Ramya Raviram, Foteini Fotopoulou, Neil G. Ruthen, Srinivas Rajagopalan, Joshua S. Schiffman, Andrew R. D’Avino, Sang-Ho Yoon, Jesús Alfonso López Sotélo, , Dan Avi Landau

This paper develops SMART-PTA for single-cell whole-genome and transcriptome sequencing, revealing clonal evolution in aged human esophageal tissue over 70 years.

bioRxiv · Oct 11, 2025 · PreprintGenomics