Author

Amandine Batté

University of LausanneORCID 0000-0002-6918-5782Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Genomics· 2

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Organism:yeast· 3 Assay:DNA methylation· 2 Research Focus:database / resource· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:variant calling· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Carles PonsiD· 3 shared Jolanda S. van LeeuweniD· 3 shared Patrick AloyiD· 3 shared Gianni LitiiD· 2 shared Leopold PartsiD· 2 shared Maykel Lopes· 2 shared Uyen Linh Ho· 2 shared Andrei ChabesiD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersGenomics

Carles PonsORCID

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Author profile →

4 papers

Recent·Most cited

The modifiers that cause changes in gene essentiality

Amandine Batté, Núria Bosch-Guiteras, Carles Pons, Marina Ota, Maykel Lopes, Sushma Sharma, Nicolò Tellini, Claire Paltenghi, Michelle M. Conti, Kwan Ting Kan, Uyen Linh Ho, Michaël Wiederkehr, J. -F. Barraud, Mark Ashe, Patrick Aloy, , Jolanda S. van Leeuwen

The paper identifies suppressor variants that alter gene essentiality across yeast strains, revealing context-dependent genetic mechanisms.

Cell Systems · Mar 2, 2026Peer-reviewedGenomics

Global analysis of suppressor mutations that rescue human genetic defects

Betül Ünlü, Carles Pons, Uyen Linh Ho, Amandine Batté, Patrick Aloy, Jolanda S. van Leeuwen

The paper identifies suppressor mutations that rescue human genetic defects by analyzing 2,400 papers and predicting suppressor genes in the human genome.

Genome Medicine · Oct 11, 2023Peer-reviewedGenomics

Sir3 Heterochromatin Protein Promotes NHEJ by Direct Inhibition of Sae2

Hélène Bordelet, Rafaël Costa, Clémentine Brocas, Jordane Dépagne, Xavier Veaute, Didier Busso, Amandine Batté, Raphaël Guérois, Stéphane Marcand, Karine Dubrana

This study shows that Sir3 promotes NHEJ by inhibiting Sae2-dependent resection through physical interaction, independent of its heterochromatin function.

bioRxiv · May 26, 2021 · PreprintGenetics

Diverse natural variants suppress mutations in hundreds of essential genes

Leopold Parts, Amandine Batté, Maykel Lopes, Michael Wai-Keong Yuen, Meredith Laver, Bryan-Joseph San Luis, Jia‐Xing Yue, Carles Pons, Elise Eray, Patrick Aloy, Gianni Liti, Jolanda S. van Leeuwen

The paper measures how natural genetic variation can suppress mutations in essential yeast genes, finding that 35% of tested genes can be suppressed by modifier genes in different backgrounds.

Molecular Systems Biology · May 1, 2021Peer-reviewedGenetics