Author

Núria Bosch-Guiteras

University of BernORCID 0000-0003-0331-0429Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:variant calling· 2 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Hugo Guillen-RamireziD· 2 shared Michaela MedováiD· 2 shared Roberta EspositoiD· 2 shared Rory JohnsoniD· 2 shared Tina Uroda· 2 shared Yitzhak ZimmeriD· 2 shared Adrian F. OchsenbeiniD· 1 shared Adrienne VancuraiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenomics

Hugo Guillen-RamirezORCID

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3 papers

Recent·Most cited

The modifiers that cause changes in gene essentiality

Amandine Batté, Núria Bosch-Guiteras, Carles Pons, Marina Ota, Maykel Lopes, Sushma Sharma, Nicolò Tellini, Claire Paltenghi, Michelle M. Conti, Kwan Ting Kan, Uyen Linh Ho, Michaël Wiederkehr, J. -F. Barraud, Mark Ashe, Patrick Aloy, , Jolanda S. van Leeuwen

The paper identifies suppressor variants that alter gene essentiality across yeast strains, revealing context-dependent genetic mechanisms.

Cell Systems · Mar 2, 2026Peer-reviewedGenomics

Tumour mutations in long noncoding RNAs enhance cell fitness

Roberta Esposito, Andrés Lanzós, Tina Uroda, Sunandini Ramnarayanan, Isabel Büchi, Taisia Polidori, Hugo Guillen-Ramirez, Ante Mihaljevic, Bernard Mefi Merlin, Lia Mela, Eugenio Zoni, Lusine Hovhannisyan, Finn McCluggage, Matúš Medo, Giulia Basile, , Rory Johnson

The paper identifies mutated long noncoding RNAs (lncRNAs) as contributors to tumour cell fitness through experimental validation of their oncogenic effects.

Nature Communications · Jun 8, 2023Peer-reviewedGenomics

Enhancing CRISPR deletion via pharmacological delay of DNA-PK

Núria Bosch-Guiteras, Tina Uroda, Hugo Guillen-Ramirez, Rahel Riedo, Amiq Gazdhar, Roberta Esposito, Carlos Pulido-Quetglas, Yitzhak Zimmer, Michaela Medová, Rory Johnson

This paper shows that temporarily inhibiting DNA-PK increases CRISPR-Cas9 deletion efficiency by delaying NHEJ, improving experimental outcomes across multiple cell lines and guide RNAs.

bioRxiv · Feb 12, 2020Molecular Biology