Author

Caleb Chang

Rice UniversityORCID 0000-0002-4507-659XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

Yang GaoiD· 2 shared Abhinav K. JainiD· 1 shared Antonello MaiiD· 1 shared Bigang Liu· 1 shared Chuxuan LiiD· 1 shared Dante RotiliiD· 1 shared Grace ZhouiD· 1 shared Jie YangiD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersMolecular Biology

Yang GaoORCID

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2 papers

Recent·Most cited

Molecular BiologyCell chemical biologyPeer-reviewedOct 21, 2024

Quinoline-based compounds can inhibit diverse enzymes that act on DNA

Jujun Zhou, Qin Chen, Ren Ren…·Xiaodong Cheng

This study identifies quinoline-based compounds that inhibit DNA methyltransferases and other DNA-targeting enzymes, with compound 11 inducing DNA damage response in cancer cells.

13 citations

humanbacteria (other)

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BiochemistryeLifePeer-reviewedJul 1, 2024

Observing one-divalent-metal-ion dependent and histidine-promoted His-Me family I-PpoI nuclease catalysis in crystallo

Caleb Chang, Grace Zhou, Yang Gao

This study uses time-resolved crystallography to investigate the catalytic mechanism of His-Me family I-PpoI nuclease, revealing the role of a single divalent metal ion and histidine in DNA hydrolysis.

1 citation

structural biologyexperimental assay

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