Author

Javier Espadas

University of GenevaORCID 0000-0002-4559-5410Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Javier Espadas1 paper

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Organism:Arabidopsis· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:comparative / phylogenetic analysis· 1 Assay:electronic health records· 1 Assay:proteomics· 1

Frequent Co-Authors

Aurélien RouxiD· 4 shared Adai ColomiD· 3 shared Buzz BaumiD· 2 shared Carlos MarcuelloiD· 2 shared Diorge Paulo de SouzaiD· 2 shared Juan Manuel GARCIA ARCOSiD· 2 shared Markku HakalaiD· 2 shared Marko KaksoneniD· 2 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersCell Biology

Aurélien RouxORCID

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4 papers

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedMay 12, 2026

Two-dimensional HRS condensates drive the assembly of flat clathrin lattices on endosomes

Markku Hakala, Satish Babu Moparthi, Iva Ganeva…·Aurélien Roux

This study shows HRS forms 2D condensates that drive flat clathrin lattice assembly on endosomes, with cholesterol enhancing this process.

4 citationstop 4%

electronic health recordsexperimental assay

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Cell BiologybioRxivPreprintNov 28, 2025

Molecular basis for cellular compartmentalization by an ancient membrane fission mechanism

Javier Espadas, Diorge Paulo de Souza, Markku Hakala…·Aurélien Roux

This study identifies an ancient membrane fission mechanism in Asgard archaea, showing ESCRT-III's role in cell compartmentalization predates eukaryogenesis.

DOI 10.1101/2025.11.28.690958

Arabidopsisyeast

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Cell BiologyNature CommunicationsPeer-reviewedNov 26, 2025

Actin dynamics sustains spatial gradients of membrane tension in adherent cells

Juan Manuel GARCIA ARCOS, Amine Mehidi, Julissa J. Sánchez‐Velásquez…·Aurélien Roux

The paper demonstrates that adherent cells maintain spatial gradients of membrane tension through actin dynamics and membrane-cortex attachments, with tension lowest at adhesion edges and highest at protrusions.

15 citations

experimental assaycell signaling & trafficking

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Evolutionary BiologyScience AdvancesPeer-reviewedFeb 7, 2025

Evolutionarily conserved principles of ESCRT-III-mediated membrane remodelling revealed by a two-subunit Asgard archaeal system

Diorge Paulo de Souza, Javier Espadas, Sami Chaaban…·Buzz Baum

The paper identifies evolutionarily conserved principles of ESCRT-III-mediated membrane remodeling using an Asgard archaeal two-subunit system, showing homology to eukaryotic ESCRT-IIIB and IIIA.

29 citationstop 1%

Arabidopsiscomparative / phylogenetic analysis

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