Author

Markku Hakala

University of GenevaORCID 0000-0002-3485-6080Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Organism:yeast· 2 Organism:Arabidopsis· 1 Research Focus:cell type annotation· 1 Assay:electronic health records· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

Marko KaksoneniD· 3 shared Adai ColomiD· 2 shared Aurélien RouxiD· 2 shared Carlos MarcuelloiD· 2 shared Christopher P. ToretiD· 2 shared Javier EspadasiD· 2 shared Alphée MichelotiD· 1 shared Andrea MerinoiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersCell Biology

Marko KaksonenORCID

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3 papers

Recent·Most cited

Evolutionarily diverged on-switch for actin assembly in fungal endocytosis

Juliette Sebellin, Fabina Binth Kandiyoth, Bagyashree VT, Andrea Picco, Nicolas Carvalho, Markku Hakala, Anne-Sophie Rivier-Cordey, Alphée Michelot, Christopher P. Toret, Marko Kaksonen

The paper identifies Ldb17 as the on-switch for endocytic actin assembly in S. cerevisiae, revealing its complex regulation by Sla1 and evolutionary divergence from Dip1 in S. pombe.

The Journal of Cell Biology · Oct 28, 2026Peer-reviewedCell Biology

Two-dimensional HRS condensates drive the assembly of flat clathrin lattices on endosomes

Markku Hakala, Satish Babu Moparthi, Iva Ganeva, Mehmet Gül, César Bernat-Silvestre, Carlos Marcuello, Javier Espadas, Adai Colom, Mikhail Kudryashev, Wanda Kukulski, Stéphane Vassilopoulos, Marko Kaksonen, Aurélien Roux

This study shows HRS forms 2D condensates that drive flat clathrin lattice assembly on endosomes, with cholesterol enhancing this process.

Nature Communications · May 12, 2026Peer-reviewedBiochemistry

Molecular basis for cellular compartmentalization by an ancient membrane fission mechanism

Javier Espadas, Diorge Paulo de Souza, Markku Hakala, Juan Manuel GARCIA ARCOS, Joshua Tran, Ashutosh Kumar, Carlos Marcuello, Andrea Merino, Adai Colom, Stefano Vanni, Marko Kaksonen, Buzz Baum, Christopher P. Toret, Aurélien Roux

This study identifies an ancient membrane fission mechanism in Asgard archaea, showing ESCRT-III's role in cell compartmentalization predates eukaryogenesis.

bioRxiv · Nov 28, 2025 · PreprintCell Biology