Hannah G. Kelly

Innate immune sensing of cell traversal by Plasmodium sporozoites drives protective T cell responses

The paper shows that Plasmodium sporozoites trigger innate immune responses via cell traversal, which is essential for activating protective CD8+ T cells.

A novel chimeric coronavirus spike vaccine combining SARS-CoV-2 RBD and scaffold domains from HKU-1 elicits potent neutralising antibody responses

A chimeric coronavirus spike vaccine combining SARS-CoV-2 RBD and HKU-1 scaffold domains elicits potent neutralising antibodies and CD4 T cell help in mice and macaques.

B cells targeting parasites capture spatially linked antigens to secure T cell help

The paper investigates how B cells targeting Plasmodium parasites capture spatially linked antigens to receive T cell help, showing that B cells can obtain help from T cells specific to surface antigens, not just the same protein.