Author

Isaac Michael Barber-Axthelm

The University of MelbourneORCID 0000-0002-7892-6802Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Adam K. WheatleyiD· 1 shared Adam Lacy‐HulbertiD· 1 shared Adelle P. McFarlandiD· 1 shared Andrew P. KellyiD· 1 shared Benjamin S. HughesiD· 1 shared Courtney E. McAleeseiD· 1 shared David A. ConstantiD· 1 shared Emily A. HemanniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperImmunology

Adam K. WheatleyORCID

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2 papers

Recent·Most cited

Lineage-specific chromatin poising enforced by ETS-IRF composite elements determines the divergent interferon responses of plasmacytoid dendritic cells and epithelial cells

Gargi Mishra, Snehal Ozarkar, Yo Okamura, Meghan Knoll, Russell Sam, Hongchuan Li, Johannes Schwerk, Adelle P. McFarland, David A. Constant, Hayley Waterman, Manasa Acharya, Adam Lacy‐Hulbert, Jason G. Smith, Michael A. Parthun, Emily A. Hemann, , Ram Savan

This paper identifies lineage-specific chromatin accessibility differences at IFN gene loci in pDCs and epithelial cells, revealing ETS-IRF composite elements as key regulators of divergent interferon responses.

bioRxiv · Jun 10, 2026 · PreprintImmunology

A novel chimeric coronavirus spike vaccine combining SARS-CoV-2 RBD and scaffold domains from HKU-1 elicits potent neutralising antibody responses

Veronica P. Zoest, Wen Shi Lee, Lydia Murdiyarso, Lauren Burmas, Phillip Pymm, Robyn Esterbauer, Andrew P. Kelly, Hannah G. Kelly, Isaac Michael Barber-Axthelm, James P. Cooney, Kathryn C. Davidson, Merle Dayton, Courtney E. McAleese, Marianne Gillard, Karen Hughes, , Hyon‐Xhi Tan

A chimeric coronavirus spike vaccine combining SARS-CoV-2 RBD and HKU-1 scaffold domains elicits potent neutralising antibodies and CD4 T cell help in mice and macaques.

npj Vaccines · Nov 28, 2025Peer-reviewedImmunology