Tom Hill

The paper designs a synthetic consensus IFN-β for bats that induces IFN-I signaling across diverse bat species, enabling study of antiviral immunity.

The paper presents the first chromosome-level nuclear genome of Simulium vittatum, linking cytogenetic features to genome organization and evolution.

The paper identifies a PI3Kδ-Foxo1-FasL signaling loop that disrupts Th2 differentiation and epigenetic regulation in CD4+ T cells.

This study benchmarks two cell-free DNA deconvolution algorithms, finding that high accuracy can be achieved at lower sequencing depths than previously thought.

The paper examines the genome and population genomics of a male-killing Wolbachia strain, identifying rapid evolution and horizontal gene transfer in specific regions.

This paper introduces a deep learning method for detecting copy number variants in short-read sequencing data, showing improved performance over traditional methods in low coverage data.

The paper examines TE dynamics across five Drosophila species, finding conserved insertion frequency patterns despite differing TE content.

The paper sequences the genome of Drosophila innubila and finds that antiviral RNAi genes evolve slowly, contrasting with Drosophila melanogaster, suggesting different evolutionary pressures for DNA and RNA virus resistance.

The paper investigates horizontal transfer of transposable elements (TEs) in the Drosophila pseudoobscura group, finding extensive exchange but also significant divergence in TE content due to varying TE activity and Y chromosome effects.

This paper sequences and analyzes the genome of Drosophila innubila nudivirus, identifying adaptation signatures and gene turnover patterns in its evolution.

The paper investigates the rapid global invasion of the P-element in Drosophila simulans and finds that it causes hybrid dysgenesis but is later suppressed by adaptive strains.

The paper shows that the P-element, previously thought absent from Drosophila simulans, has recently invaded its populations via horizontal transfer from D. melanogaster.