Nancy L. Saccone

This paper develops a polygenic score for smoking persistence and finds it is associated with earlier or later cessation ages across diverse populations.

GEM-Net constructs multi-modal gene networks using harmonized omics data from the Long Life Family Study, revealing a microbiome-immune axis linked to metabolic health.

The paper proposes using cell fitness as a universal phenotype to prioritize gene and drug targets in disease research, showing its broad applicability across diseases and cost-effectiveness.

The paper tests the regulatory activity of human LTR18A transposable elements and finds they have lost activity over time due to mutations in AP-1 and C/EBP motifs.

The paper identifies novel genetic loci associated with nicotine dependence and shows genetic correlations with other smoking traits and comorbidities using genome-wide association studies.

The paper compares genome-wide data from opioid use and dependence cases to identify genetic associations and differences between exposure and dependence.

This study conducts a trans-ancestral GWAS of alcohol dependence, identifying genetic variants and correlations with psychiatric disorders.