Nelson V. Simwela

This study identifies the GID/CTLH complex as a regulator of metabolism and innate immunity in macrophages infected with Mycobacterium tuberculosis through ubiquitylation profiling and functional analysis.

This paper develops a 96-well plate assay to identify anti-TB drugs effective against drug-tolerant Mtb in macrophages, showing host immune stresses can induce tolerance or synergize with certain drugs.

This study shows that impaired macrophage fatty acid metabolism limits Mycobacterium tuberculosis growth through multiple anti-microbial mechanisms.

The paper identifies the GID/CTLH complex as a host determinant suppressing antimicrobial responses against intracellular bacterial infections through a CRISPR screen in Mtb-infected macrophages.