Author

Luana Johnston

Cornell UniversityORCID 0000-0003-1224-8241Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

David G. RusselliD· 3 shared Nelson V. SimwelaiD· 3 shared Christopher M. SassettiiD· 2 shared Bom Nae Rin LeeiD· 1 shared Craig AltieriD· 1 shared Eleni JaeckleiniD· 1 shared Greana KirubakariD· 1 shared Paulina Pavinski Bitar· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 20 mutual co-author links

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3 shared papersImmunology

David G. RussellORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

ImmunologyPLoS PathogensPeer-reviewedSep 18, 2026

Ubiquitylation by the GID/CTLH complex regulates the metabolic and innate immune response of macrophages to infection by Mycobacterium tuberculosis

Nelson V. Simwela, Luana Johnston, Christopher M. Sassetti, David G. Russell

This study identifies the GID/CTLH complex as a regulator of metabolism and innate immunity in macrophages infected with Mycobacterium tuberculosis through ubiquitylation profiling and functional analysis.

DOI 10.1371/journal.ppat.1014196

humanproteomics

𝕏 PostBluesky

MicrobiologyAntimicrobial Agents and ChemotherapyPeer-reviewedSep 11, 2025

Incorporation of macrophage immune stresses into an assay for drug tolerance in intracellular Mycobacterium tuberculosis

Greana Kirubakar, Luana Johnston, Bom Nae Rin Lee…·Nelson V. Simwela

This paper develops a 96-well plate assay to identify anti-TB drugs effective against drug-tolerant Mtb in macrophages, showing host immune stresses can induce tolerance or synergize with certain drugs.

3 citations

mouseproteomics

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ImmunologyNature CommunicationsPeer-reviewedOct 29, 2024

Genome-wide screen of Mycobacterium tuberculosis-infected macrophages identified the GID/CTLH complex as a determinant of intracellular bacterial growth.

Nelson V. Simwela, Luana Johnston, Paulina Pavinski Bitar…·David G. Russell

The paper identifies the GID/CTLH complex as a host determinant suppressing antimicrobial responses against intracellular bacterial infections through a CRISPR screen in Mtb-infected macrophages.

30 citationstop 1%

genetic perturbation / CRISPRhost-pathogen & immune response

𝕏 PostBluesky