Xin Shan

The paper maps tertiary lymphoid structures in intrahepatic cholangiocarcinoma, identifying immune niches and their association with clinical outcomes.

This paper introduces CAR-T-drug conjugates (CAR-T-D-C) to improve CAR-T therapy for solid tumors by combining chemotherapy with CAR-T cells, enhancing tumor infiltration and immune response.

Perturb-DBiT co-sequences spatial transcriptomes and gRNAs on one tissue section, supporting genome-wide in vivo CRISPR screens in FFPE and fresh-frozen tumors across three cancer models.

The paper identifies actin capping proteins as key modulators of therapeutic responses to radiation and immunotherapy through genome-scale CRISPR screens in melanoma cells.