Ping Ren

Engineered CTLA-4 targeting chimeras for targeted protein degradation and immune synapse reprogramming

This paper introduces cTACs, synthetic molecules that degrade PD-L1 across immune and tumor cells, enhancing T cell activation and tumor suppression in vivo.

CAR-T-drug conjugate against solid tumor

This paper introduces CAR-T-drug conjugates (CAR-T-D-C) to improve CAR-T therapy for solid tumors by combining chemotherapy with CAR-T cells, enhancing tumor infiltration and immune response.

Sensitive detection of synthetic response to cancer immunotherapy driven by gene paralog pairs

The paper identifies paralog pairs that enhance cancer immunotherapy efficacy through computational analysis and experimental validation.

Genome scale CRISPR screens identify actin capping proteins as key modulators of therapeutic responses to radiation and immunotherapy

The paper identifies actin capping proteins as key modulators of therapeutic responses to radiation and immunotherapy through genome-scale CRISPR screens in melanoma cells.