Author

Felipe Santos Simões de Freitas

University College LondonORCID 0000-0003-4627-3509Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

David AttwelliD· 2 shared Chanawee HirunpattarasilpiD· 1 shared Greg JamesiD· 1 shared Huma SethiiD· 1 shared Jiandong HuoiD· 1 shared Josef T. KittleriD· 1 shared Lowri EvansiD· 1 shared Raymond J. OwensiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 24 mutual co-author links

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2 shared papersPhysiology

David AttwellORCID

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2 papers

Recent·Most cited

PhysiologybioRxivPreprintJun 26, 2025

Relaxation of cardiac pericytes by GLP-1 activating KATP channels mediates remote ischaemic preconditioning cardioprotection

Svetlana Mastitskaya, Felipe Santos Simões de Freitas, Lowri Evans, David Attwell

This study shows that remote ischaemic preconditioning protects the heart by releasing GLP-1, which relaxes cardiac pericytes and reduces no-reflow.

DOI 10.1101/2025.06.26.661857

mouseexperimental assay

𝕏 PostBluesky

NeurosciencebioRxivPreprintApr 1, 2021

SARS-CoV-2 binding to ACE2 triggers pericyte-mediated angiotensin-evoked cerebral capillary constriction

Chanawee Hirunpattarasilp, Greg James, Felipe Santos Simões de Freitas…·David Attwell

This study shows SARS-CoV-2 binding to ACE2 on pericytes enhances angiotensin II-induced cerebral capillary constriction via AT1 receptors, suggesting AT1 blockers may mitigate brain blood flow reduction in infection.

15 citations

𝕏 PostBluesky