High-throughput Oligopaint screen identifies druggable regulators of genome folding
Daniel S. Park, Son C. Nguyen, Randi L Isenhart, Parisha P. Shah, Won–Ho Kim, R. Jordan Barnett, Aditi Chandra, Jennifer M. Luppino, Jailynn Harke, May Wai, Patrick J. Walsh, Richard J. Abdill, Rachel Yang, Yemin Lan, Sora Yoon, , Eric F. Joyce
The paper develops HiDRO, a high-throughput imaging pipeline, to screen the human druggable genome and identifies >300 factors regulating chromatin folding, including GSK3A as a regulator of TAD interactions.
Nature · Jul 12, 2023Peer-reviewedGenetics