Ana Paula Luiz

Analgesic targets identified in mouse sensory neuron somata and terminal pain translatomes

The paper identifies analgesic targets in mouse sensory neurons by analyzing translatomes in somata and terminals under different pain conditions.

Chemogenetic silencing of NaV1.8 positive sensory neurons reverses chronic neuropathic and bone cancer pain in FLEx PSAM4-GlyR mice

Molecular basis of FAAH-OUT-associated human pain insensitivity

The paper identifies how the FAAH-OUT lncRNA regulates FAAH expression through DNA methylation and enhancer activity, linking it to pain insensitivity.

Pregabalin silences oxaliplatin-activated sensory neurons to relieve cold allodynia

This study shows pregabalin reduces cold allodynia caused by oxaliplatin by silencing specific sensory neurons through the 2{delta}-1 subunit of voltage-gated calcium channels.

Sensitization of cutaneous primary afferents in bone cancer revealed by in vivo calcium imaging

The paper investigates changes in bone-innervating afferents in cancer-induced bone pain using calcium imaging and retrograde labeling, finding altered excitability in cutaneous afferents but not bone marrow afferents.

The mechanism of analgesia in Nav1.7 null mutants

This study identifies opioid-dependent inhibition of neurotransmitter release as the primary mechanism of analgesia in NaV1.7 null mutants in mice and humans.

Silent cold-sensing neurons drive cold allodynia in neuropathic pain states

The paper identifies silent cold-sensing neurons that become active in neuropathic pain and contribute to cold allodynia through peripheral sensitization.

Sensory neuron-derived Nav1.7 contributes to dorsal horn neuron excitability

This study shows that Nav1.7 from sensory neurons affects dorsal horn neuron excitability, with functional effects not predicted by mRNA levels.