Aaron D. Wolfe

The paper develops and validates a genetically encoded fluorescent sensor, iG6PSnFR, for measuring glucose-6-phosphate dynamics across multiple biological contexts.

SynaptoTagMe enables in vivo mapping and modulation of neurotransmission at single-cell resolution in C. elegans by fluorescently labeling and ablating vesicular transporters.

The paper develops a multisensor framework in C. elegans neurons to study redox constraints on glycolysis, showing that redox state modulates glycolytic activity and neuronal function.

The paper shows that glycolytic specialization in two C. elegans neurons shapes their biophysical properties and functional roles in vivo.

The paper investigates tissue-specific metabolic functions of GPI-1 in C. elegans, showing isoform-specific localization and metabolic roles in different tissues.

This study identifies PYGL-1 as essential for glycolytic plasticity in neurons, revealing two mechanisms that support synaptic function under metabolic stress.

The paper uses a biosensor to image glycolysis in individual neurons of C. elegans, revealing diverse and adaptable glycolytic states across cell types and conditions.