Author

Benjamin Clark

Yale UniversityORCID 0000-0002-0306-3184Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Organism:C. elegans· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Daniel A. Colón‐RamosiD· 4 shared Ian J. GonzaleziD· 2 shared Laura ManningiD· 2 shared Sarah E. EmersoniD· 2 shared Sarah E. Kargbo-HilliD· 2 shared Sisi YangiD· 2 shared Xuan ZhaoiD· 2 shared Aaron D. WolfeiD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersNeuroscience

Daniel A. Colón‐RamosORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Physical contact reveals a hidden layer of cortical architecture

Jordan Matelsky, Hannah Martinez, Michael S. Robinette, Katharine Merfeld, Daniel Xenes, Cara J. Cavanaugh, Sarah E. Emerson, Dhananjay Bhaskar, Benjamin Clark, Caitlyn A. Bishop, Konrad Paul Kording, Daniel Colón-Ramos, Patricia K. Rivlin, Cody J. Smith, Brock A. Wester

The paper maps physical cell-cell contacts in mouse visual cortex, revealing a dense contactome that exceeds synaptic connectivity and highlights the role of astrocytes in shaping the neural microenvironment.

bioRxiv · May 8, 2026 · PreprintNeuroscience

Spatial Partitioning of Glucose Metabolism Supports Tissue-Specific Metabolic Programs In Vivo

Ian J. Gonzalez, Aaron D. Wolfe, Benjamin Clark, Michael Hanna, Gabrielle E. Geise, Quishi Sun, Snusha Ravikumar, Anastasia Tsives, Sarah E. Emerson, Stephan Siebel, Richard Glenn Kibbey, L. Safak Yilmaz, Albertha J.M. Walhout, Daniel A. Colón‐Ramos

The paper investigates tissue-specific metabolic functions of GPI-1 in C. elegans, showing isoform-specific localization and metabolic roles in different tissues.

bioRxiv · Nov 9, 2025 · PreprintCell Biology

Genomic deletion and duplication effects on cognitive ability lie at the opposing ends of the cortical sensorimotor-association hierarchy

Kuldeep Kumar, Sayeh Kazem, Jane Yang, Florian Bénitière, Mame Seynabou Diop, Benjamin Clark, Guillaume Huguet, Worrawat Engchuan, Jakub Kopál, Thomas Renne, Omar Shanta, Bhooma Thiruvahindrapuram, Jeffrey R. MacDonald, Josephine Mollon, Laura M. Schultz, , Sébastien Jacquemont

The paper develops a method to analyze genomic deletions and duplications across the cerebral cortex and finds opposing effects on cognitive ability depending on gene expression patterns in different cortical regions.

bioRxiv · Jan 6, 2025 · PreprintNeuroscience

The active zone protein Clarinet regulates ATG-9 trafficking at synapses and presynaptic autophagy

Xuan Zhao, Sisi Yang, Sarah E. Kargbo-Hill, Benjamin Clark, Laura Manning, Daniel A. Colón‐Ramos

This study identifies CLA-1L's role in regulating ATG-9 trafficking and presynaptic autophagy through interactions with endocytic proteins.

PLoS Biology · Apr 13, 2023Peer-reviewedNeuroscience

Presynaptic autophagy is coupled to the synaptic vesicle cycle via ATG-9

Sisi Yang, Daehun Park, Laura Manning, Sarah E. Kargbo-Hill, Mian Cao, Xuan Zhao, Ian J. Gonzalez, Yongming Dong, Benjamin Clark, Lin Shao, Ifechukwu Okeke, Agustin Almoril-Porras, Jihong Bai, Pietro V. De Camilli, Daniel A. Colón‐Ramos

This study identifies ATG-9 trafficking as a mechanism linking presynaptic autophagy to the synaptic vesicle cycle in C. elegans.

Neuron · Jan 21, 2022Peer-reviewedNeuroscience