Francina Langa Vives

Slap restricts oncogenic Src-family kinase signaling to maintain colonic epithelial homeostasis

This study identifies SLAP as a tumor suppressor that limits SFK activity in colonic epithelial cells, preventing tumorigenesis and hyperproliferation.

ILC3s are Required for Enterocyte Homeostasis to Food Intake

This study shows that ILC3s prevent post-prandial inflammation by regulating enterocyte metabolism during food intake.

Mutant CHCHD10 disrupts cytochrome c oxidation and activates retrograde signaling in a model of cardiomyopathy.

This study shows that mutant CHCHD10 causes mitochondrial dysfunction and cardiomyopathy by disrupting cytochrome c oxidation and activating retrograde signaling.

Nr5a2 is essential for morula development

This study shows Nr5a2 is essential for morula development in mice, as its absence causes embryonic arrest, lineage specification issues, and genome instability.

The R2TP chaperone assembles cellular machineries in intestinal CBC stem cells and progenitors

This study investigates the role of the R2TP chaperone in intestinal stem and progenitor cells, showing its critical function in proliferation and its association with poor colorectal cancer prognosis.

Dissection of the Fgf8 regulatory landscape by in vivo CRISPR-editing reveals extensive inter- and intra-enhancer redundancy

The paper uses in vivo CRISPR editing to analyze Fgf8 regulatory elements in the AER and MHB, revealing distinct patterns of enhancer redundancy and function.

A distinct cardiopharyngeal mesoderm genetic hierarchy establishes antero-posterior patterning of esophagus striated muscle

The paper identifies a genetic hierarchy involving Tbx1, Isl1, and Met/HGF signaling that regulates antero-posterior patterning of esophagus striated muscle in mice.