Author

Víctor R. Vázquez Marrero

University of PennsylvaniaORCID 0000-0002-5134-3244Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Organism:mouse· 1

Frequent Co-Authors

Sunny ShiniD· 3 shared Allyson Lu· 2 shared Madison DresleriD· 2 shared Mikel D. HaggadoneiD· 2 shared Aaron Wu· 1 shared Aoife O’FarrelliD· 1 shared Arjun RajiD· 1 shared Brian P. GoldspieliD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersImmunology

Sunny ShinORCID

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3 papers

Recent·Most cited

Environmental Amino Acid Sensing Regulates the Rate of ASC Translation and NLRP3 Inflammasome Assembly

Mikel D. Haggadone, Brian P. Goldspiel, Aoife O’Farrell, Nora T. Kiledjian, Montana Knight, Talia Smith, Elena Anderson, Víctor R. Vázquez Marrero, Mark A. Boyer, Peining Jimmy Xu, Michael Scaglione, Zachary M. Powers, Clémence Queriault, Aaron Wu, Qihua Yang, , Will Bailis

This study shows that environmental branched-chain amino acids regulate ASC translation and NLRP3 inflammasome assembly through mTOR-dependent translational bursting.

bioRxiv · Jan 20, 2026 · PreprintImmunology

Dendritic cells activate pyroptosis and effector-triggered apoptosis to restrict Legionella infection

Víctor R. Vázquez Marrero, Jessica Doerner, Kimberly A. Wodzanowski, Jenna Zhang, Allyson Lu, Frankie D. Boyer, Isabel Vargas, Suzana Hossain, Karly B. Kammann, Madison Dresler, Sunny Shin

This study shows that dendritic cells use pyroptosis and effector-triggered apoptosis to restrict Legionella infection, contrasting with macrophages that support bacterial replication.

mBio · Jun 18, 2025Peer-reviewedImmunology

GM-CSF engages multiple signaling pathways to enhance pro-inflammatory cytokine responses in human monocytes during Legionella infection

Víctor R. Vázquez Marrero, Madison Dresler, Mikel D. Haggadone, Allyson Lu, Sunny Shin

This study shows GM-CSF enhances cytokine production in human monocytes during Legionella infection through multiple signaling pathways.

Infection and Immunity · Jun 5, 2025Peer-reviewedImmunology