Author

Leen Janssen

University Medical Center GroningenORCID 0000-0002-1973-304XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:C. elegans· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Ellen A. A. NolleniD· 3 shared Esther Stroo· 2 shared Mandy KoopmaniD· 2 shared Wytse Hogewerf· 2 shared Alain de BruiniD· 1 shared Alejandro Mata‐CabanaiD· 1 shared Amantha ThathiahiD· 1 shared Anita PrasiD· 1 shared

Activity by Year

2021-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersMolecular Biology

Ellen A. A. NollenORCID

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3 papers

Recent·Most cited

The cellular modifier MOAG-4/SERF drives amyloid formation through charge complementation

Anita Pras, Bert Houben, Francesco A. Aprile, Renée I. Seinstra, Rodrigo U. Gallardo, Leen Janssen, Wytse Hogewerf, Christian Gallrein, Matthias De Vleeschouwer, Alejandro Mata‐Cabana, Mandy Koopman, Esther Stroo, Minke de Vries, Samantha Louise Edwards, Janine Kirstein, , Ellen A. A. Nollen

The paper identifies MOAG-4/SERF as modifiers of amyloid formation through charge complementation, showing that charge interactions drive protein aggregation and toxicity.

The EMBO Journal · Oct 7, 2021Peer-reviewedMolecular Biology

Optogenetic manipulation of individual or whole population Caenorhabditis elegans worms with an under hundred-dollar tool: the OptoArm

Mandy Koopman, Leen Janssen, Ellen A. A. Nollen

The paper introduces an affordable optogenetic device called OptoArm for manipulating C. elegans worms, showing that cholinergic neurons decline with age while GABAergic neurons and muscle cells remain resilient.

bioRxiv · Mar 19, 2021 · PreprintGenetics

SERF deletion modifies amyloid aggregation in a mouse model of Alzheimer's disease

Esther Stroo, Leen Janssen, Olga Sin, Wytse Hogewerf, Mirjam H. Koster, Liesbeth Harkema, Sameh A. Youssef, Natalie Beschörner, Anouk H. G. Wolters, Björn Bakker, Lore Becker, Lillian Garrett, Susan Marschall, Sabine M. Hölter, Wolfgang Wurst, , Ellen A. A. Nollen

This study shows that SERF2 deletion changes amyloid fibril structure in Alzheimer's mouse models, suggesting SERF's role in modifying amyloid aggregation.

bioRxiv · Jan 5, 2021 · PreprintMolecular Biology