Author

Bryan Kwok

Drexel UniversityORCID 0000-0002-5178-8219Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:flow cytometry· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

Lin Han BiD· 3 shared Robert L. MauckiD· 3 shared Biao HaniD· 2 shared Chao WangiD· 2 shared David E. BirkiD· 2 shared Mingyue FaniD· 2 shared Renato V. IozzoiD· 2 shared Sung Yeon KimiD· 2 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersBiophysics

Lin Han BORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Decorin-mediated Extracellular Matrix Stabilization Maintains Cartilage Integrity During Aging

Mingyue Fan, Thomas Li, Aanya Mohan, Biao Han, Michael D. Newton, Bryan Kwok, Yuchen Liu, Sung Yeon Kim, Chao Wang, Jiaqi Xiang, Ling Qin, Renato V. Iozzo, David E. Birk, X. Lucas Lu, Claudia Loebel, , Lin Han B

This study identifies decorin-mediated extracellular matrix stabilization as a key factor in maintaining cartilage integrity during aging, showing its role in preventing age-associated osteoarthritis.

bioRxiv · Aug 1, 2026 · PreprintBiophysics

Decorin promotes nascent proteoglycan retention in cartilage matrix by strengthening collagen II-aggrecan integration

Thomas Li, Gabriela Canziani, Yuchen Liu, Neil Patel, Biao Han, Mingyue Fan, Annie Porter, Bryan Kwok, Chao Wang, Qing Li, David E. Birk, Renato V. Iozzo, IRWIN M. CHAIKEN, X. Lucas Lu, Robert L. Mauck, Lin Han B

This study shows decorin strengthens collagen II-aggrecan integration in cartilage matrix, reducing aggrecan loss and supporting its therapeutic potential for osteoarthritis.

Acta Biomaterialia · Jun 9, 2026Peer-reviewedBiophysics

Mechano-activation of synovial fibroblasts and macrophages during OA progression in the dynamically stiffening synovial microenvironment

Sung Yeon Kim, Easton C. Farrell, Kevin G. Burt, Bryan Kwok, Qiushi Liang, Alexander J. Knights, Kate L. Sharp, Vu Nguyen, Lance A. Murphy, Baofeng Hu, Alexandra Kahn, Ling Qin, Lin Han B, Tristan Maerz, Rob Mauck, Carla R. Scanzello

This study investigates how synovial microenvironment stiffness changes during OA progression and how it affects fibroblast and macrophage behavior through mechanosignaling and cell-cell interactions.

bioRxiv · Feb 18, 2026 · PreprintBioengineering