Author

Esak Lee

Cornell UniversityORCID 0000-0002-5328-6677Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Alonso TapiaiD· 1 shared Andrew D. Miller· 1 shared Anthony Max CheniD· 1 shared Dongqiang Yuan· 1 shared Elijah Bacchus· 1 shared Hening LiniD· 1 shared Irma R. FernandeziD· 1 shared Issahy CanoiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCell Biology

Alonso TapiaORCID

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2 papers

Recent·Most cited

Mapping Endothelial-Macrophage Interactions in Diabetic Vasculature: Role of TREM2 in Vascular Inflammation and Ischemic Response

Naseeb Kaur Malhi, Yingjun Luo, Muxi Chen, Xiaofang Tang, Dongqiang Yuan, Rahuljeet Singh Chadha, Alonso Tapia, Shufan Yin, Xuejing Liu, Meirigeng Qi, Marpadga A. Reddy, Jiawei Sun, James C. Otto, Lu Wei, John P. Cooke, , Zhen Bouman Chen

This study maps endothelial-macrophage interactions in diabetic vasculature using single-cell and spatial transcriptomics, identifying TREM2 as a key driver of vascular inflammation and ischemic response in diabetes.

Science Translational Medicine · Apr 22, 2026Peer-reviewedCell Biology

SIRT5 acts in the tumor microenvironment via endothelial cell metabolism to support breast cancer growth

Anthony Max Chen, Issahy Cano, Qian Zhao, Pei-Yin Tsai, Elijah Bacchus, Sadhan Jana, Irma R. Fernandez, Zeribe C. Nwosu, Andrew D. Miller, Joeva J. Barrow, Hening Lin, Esak Lee, Robert S. Weiss

This study identifies SIRT5 as a regulator of endothelial cell metabolism in the tumor microenvironment, showing its role in supporting breast cancer growth through vascular function.

bioRxiv · Apr 13, 2026 · PreprintCancer Biology