James F. Markworth

The annexin A1 mimetic peptide Ac2-26 promotes inflammation-resolution and stimulates skeletal muscle regeneration in the mdx mouse model of Duchenne muscular dystrophy

This study shows that the ANXA1 mimetic peptide Ac2-26 reduces inflammation and improves skeletal muscle regeneration in mdx mice, offering a potential steroid-sparing therapy for DMD.

Dietary omega-6 arachidonic acid and omega-3 docosahexaenoic acid supplementation differentially impact skeletal muscle inflammaging in mice

This study shows that long-term dietary ARA and DHA supplementation have different effects on aging muscle structure and function in mice.

Long-chain Polyunsaturated Fatty Acids Mitigate In Vitro Skeletal Muscle Wasting Induced by Colorectal Carcinoma Cells via a 15-LOX-dependent Pathway

This study shows that specific long-chain polyunsaturated fatty acids (LC-PUFAs) reduce CRC-induced muscle wasting in vitro by activating 15-LOX-dependent pathways and producing specialized pro-resolving lipid mediators.

C26 and CT26 colorectal cancer models exhibit divergent cachexia phenotypes, intramuscular inflammation, and protein turnover signaling

This study compares C26 and CT26 colorectal cancer models, finding that C26 induces more severe cachexia, inflammation, and muscle protein turnover disruption than CT26.

Rapid High-Throughput Analysis of Bovine Skeletal Muscle Fiber Morphology via Automated Fluorescent Microscopy and MuscleBos software

Aspirin hastens resolution of skeletal muscle inflammation and promotes recovery of muscle strength following acute injury

This study shows that aspirin promotes muscle strength recovery and inflammation resolution after injury, unlike other NSAIDs which impair muscle regeneration.

Deuterated Polyunsaturated Fatty Acids Alleviate In Vitro Skeletal Muscle Dysfunction Induced by Oxidative Stress

This study shows deuterated PUFAs reduce oxidative stress-induced skeletal muscle dysfunction by limiting lipid peroxidation and modulating antioxidant responses.

Leukocyte-type 12/15-lipoxygenase is essential for timely inflammation-resolution and effective tissue regeneration following skeletal muscle injury

This study shows that 12/15-LOX is essential for inflammation resolution and skeletal muscle regeneration by regulating lipid mediators and myogenic progenitor cell function.