Author

Pier Paolo Pandolfi

Beth Israel Deaconess Medical CenterORCID 0000-0002-5352-5295Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:benchmarking· 1 Assay:CRISPR screen· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Alevtina Pavlenco· 1 shared Chao CheniD· 1 shared Daisy W. LeungiD· 1 shared Francesca ColavitaiD· 1 shared Gaya K. AmarasingheiD· 1 shared Giulia MatusaliiD· 1 shared Giuseppe NovelliiD· 1 shared J.B. Gupta· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperSynthetic Biology

Alevtina Pavlenco

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Tetravalent SARS-CoV-2 Neutralizing Antibodies Show Enhanced Potency and Resistance to Escape Mutations

Shane Miersch, Zhijie Li, Reza Saberianfar, Mart Ustav, James Brett Case, Levi L. Blazer, Chao Chen, Wei Ye, Alevtina Pavlenco, Maryna Gorelik, Julia Garcia Perez, Suryasree Subramania, Serena Singh, Lynda Ploder, Safder S. Ganaie, , Sachdev S. Sidhu

This paper develops tetravalent SARS-CoV-2 neutralizing antibodies that are more potent and resistant to escape mutations than bivalent versions.

Journal of Molecular Biology · Jul 28, 2021Peer-reviewedSynthetic Biology

Optimized RNA-targeting CRISPR/Cas13d technology outperforms shRNA in identifying essential circRNAs

Yang Zhang, Tuan M. Nguyen, Xiao-Ou Zhang, Limei Wang, Tin Phan, John G. Clohessy, Pier Paolo Pandolfi

This study compares shRNA and CRISPR/Cas13d screens for circRNA function, finding that optimized CRISPR/Cas13d reduces false positives and identifies true functional circRNAs.

Genome biology · Jan 21, 2021Peer-reviewedMolecular Biology