Potent activation of SARM1 by NMN analogue VMN underlies vacor neurotoxicity
Andrea Loreto, Carlo Angeletti, Weixi Gu, Andrew Osborne, Bart Nieuwenhuis, Jonathan Gilley, Peter Arthur‐Farraj, Elisa Merlini, Adolfo Amici, Zhenyao Luo, Lauren Hartley-Tassell, Thomas Ve, Laura M. Desrochers, Qi Wang, Boštjan Kobe, , Michael P. Coleman
This study identifies VMN, a metabolite of the pesticide vacor, as a potent SARM1 activator, showing that SARM1 removal rescues vacor-induced neuron and axon death.
eLife · Dec 6, 2021Peer-reviewedNeuroscience