Wolfram Seifert-Dávila

Recruitment of Fpt1 to tRNA genes requires TFIIIB and the N-terminal TPR array of TFIIIC subunit {tau}131

The paper investigates how Fpt1 is recruited to tRNA genes in budding yeast, revealing a dual role of TFIIIB and TFIIIC in its binding under different RNAPIII conditions.

Structural and kinetic insights into tRNA promoter engagement by yeast general transcription factor TFIIIC

This study uses cryo-EM and smFRET to reveal structural and kinetic details of yeast TFIIIC engagement with tRNA promoter DNA motifs.

Structural insights into human TFIIIC promoter recognition

This study presents cryo-EM structures of human TFIIIC complex bound to a tRNA gene, revealing how it recognizes promoter motifs and facilitates Pol III activation.

Identification of unknown proteins in X-ray crystallography and cryo-EM

The paper presents an automated pipeline to identify protein sequences from cryo-EM and crystallographic data, demonstrating its application on an unknown snake venom protein.