Author

Sara Polletti

European Institute of OncologyORCID 0000-0002-5433-0502Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Amir HosseiniiD· 1 shared Antonello MaiiD· 1 shared Chiara SorianiiD· 1 shared Elena CeccacciiD· 1 shared Emanuel SodaiD· 1 shared Emanuela VillaiD· 1 shared Enrique BlancoiD· 1 shared Federico ComoglioiD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperCancer Biology

Amir HosseiniORCID

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2 papers

Recent·Most cited

Cell cycle control of chromatin creates a therapeutic window for epigenetic therapy in tumors

Kourosh Hayatigolkhatmi, Riccardo Valzelli, Elena Ceccacci, Amir Hosseini, Oualid El Menna, Mauro Romanenghi, Isabella Pallavicini, Emanuel Soda, Ornella Ejlli, Emanuela Villa, Paolo Falvo, Pedro Vizán, Enrique Blanco, Sergi Aranda, Roxana Barkhordar, , Saverio Minucci

This paper shows that extending G1 phase in cancer cells creates a therapeutic window for epigenetic drugs, with LSD1 inhibition and CDK4/6 inhibition working synergistically to induce differentiation and improve survival in AML models.

bioRxiv · Sep 6, 2026 · PreprintCancer Biology

Dissection of acute stimulus-inducible nucleosome remodeling in mammalian cells

Federico Comoglio, Marta Simonatto, Sara Polletti, Xin Liu, Stephen T. Smale, Iros Barozzi, Gioacchino Natoli

The paper develops a framework to analyze nucleosome remodeling in response to stimuli and finds that remodeling preferentially affects poorly positioned nucleosomes at enhancers.

Genes & Development · Sep 1, 2019Peer-reviewedGenomics