Isabelle Baconguis

Conformational plasticity of human acid-sensing ion channel 1a

This study presents cryo-EM structures of human ASIC1a across different pH levels and conditions, revealing conformational changes linked to channel function.

Differential Assembly of Native ENaC Complexes Across Mouse Epithelial Tissues

This study uses a knock-in mouse model to analyze native ENaC complexes in different tissues, revealing tissue-specific differences in channel abundance and complex size.

Structural Insights into Subunit-Dependent Functional Regulation in Epithelial Sodium Channels

The paper determines the structures of three ENaC complexes, revealing how subunit composition affects channel function through structural rearrangements.

Tweek-dependent formation of ER-PM contact sites enables astrocyte phagocytic function and remodeling of neurons

This study shows Tweek is essential for astrocyte phagocytosis and ER-PM contact formation during neuronal remodeling in Drosophila.

Highly sensitive genetically-encoded sensors for population and subcellular imaging of cAMP in vivo

The paper develops improved genetically-encoded cAMP sensors, cAMPFIREs, for high-sensitivity in vivo imaging of cAMP dynamics in neurons and Drosophila.