Tianyi Mao

iFLiP: accessible and low-cost lifetime fiber photometry for robust longitudinal and quantitative measurements of neural dynamics

Comprehensive 3D mapping reveals distinct spatial gradients of SST, PV, and TH interneurons across the mouse caudoputamen

The paper creates a 3D atlas of SST, PV, and TH interneurons in the mouse caudoputamen, revealing distinct spatial distributions across striatal territories.

Neuronal architecture of the mouse insular cortex underlying its diverse functions

The paper maps neuronal diversity in the mouse insular cortex, identifying distinct morphological and functional types that underlie its diverse roles.

A high-performance genetically encoded sensor for cellular imaging of PKC activity in vivo

The paper introduces a genetically encoded fluorescence sensor for PKC activity, demonstrating its use in vivo and identifying PKC activity in specific neurons during locomotion.

Thalamic integration of basal ganglia and cerebellar circuits during motor learning

The paper identifies thalamic neurons that integrate signals from the basal ganglia and cerebellum during motor learning and shows their critical role in motor task execution.

Fine-tuning TrailMap: The utility of transfer learning to improve the performance of deep learning in axon segmentation of light-sheet microscopy images

This paper improves axon segmentation in light-sheet microscopy images by fine-tuning the TrailMap model with expert-labeled data, achieving better recall and adjusted F1-score.

Highly sensitive genetically-encoded sensors for population and subcellular imaging of cAMP in vivo

The paper develops improved genetically-encoded cAMP sensors, cAMPFIREs, for high-sensitivity in vivo imaging of cAMP dynamics in neurons and Drosophila.

Distinct in vivo dynamics of excitatory synapses onto cortical pyramidal neurons and inhibitory interneurons

The paper uses in vivo imaging to compare synaptic dynamics between excitatory synapses on pyramidal neurons and inhibitory interneurons, finding that PV+ synapses are more stable and less heterogeneous.

Synapse-specific Opioid Modulation of Thalamo-cortico-striatal Circuits

This study investigates how opioids modulate glutamate transmission in thalamo-cortico-striatal circuits in mice, revealing distinct effects of mu- and delta-opioid receptors on neural activity.